纸基微流控芯片原纸的构建及其对颜色信号均匀性的优化研究

Construction of Microfluidic Paper-based Analytical Device Base Paper and Optimization of Color Signal Uniformity

关键词:  纸基微流控  纸张  比色检测  颜色均匀性

Key Words:microfluidic paper-based analytical devices  paper  colorimetric detection  color uniformity

摘要:为了提高纸基芯片比色检测结果的均匀性，对漂白硫酸盐松木浆进行PFI磨浆处理，制备实验室原纸。与常用于构建纸基芯片的滤纸进行对比，本研究制备的纸基底表现出良好的颜色均匀性。在Fe²⁺比色检测中，该纸基芯片分析响应在1~75 mg/L范围内线性相关良好（R²=0.9599），检测下限为0.4 mg/L，并成功实现了对实际水样中Fe²⁺的（半）定量检测。

Abstract:In order to improve the uniformity of paper-based colorimetric signals， bleached kraft pine wood pulp was subjected to PFI refining treatment to prepare lab handsheets. Compared with the filter paper commonly used to construct paper-based chips， the handsheets prepared in this study showed good color uniformity. In the colorimetric detection of Fe²⁺， the analytical response of the paper-based chip had a good linear correlation in the range of 1~75 mg/L， R²=0.9599， and the detection limit was 0.4 mg/L. It had been successfully applied to the （semi）quantitative detection of Fe²⁺ in actual water samples.