细菌纤维素功能化改性及其在伤口敷料中的应用研究进展

Research Progress of Functionalized Bacterial Cellulose and Its Application in Wound Dressing

关键词:  细菌纤维素  伤口敷料  功能化改性

Key Words:bacterial cellulose  wound dressing  functional modification

摘要:细菌纤维素因具有生物可降解性、高结晶度、生物合成的可调控性等特点，被用于制备抗菌、自愈合可注射和增殖性伤口敷料的基质。由于细菌纤维素本身不具备抗菌、自愈合和止血生肌作用，因此需要对其进行功能化改性。本文总结了细菌纤维素的结构、生物合成原理和制备方法，对比分析了细菌纤维素化学、物理和生物等功能化改性技术与原理，介绍了功能化细菌纤维素在伤口敷料的应用，并对其在伤口敷料应用的发展前景进行了展望。

Abstract:Bacterial cellulose is usually used to prepare antibacterial， self-healing， injectable， and proliferative wound dressings due to its biodegradability， high crystallinity， and the adjustable nature of biosynthesis. However， bacterial cellulose needs to further be multi-functionalized in order to improve its antibacterial， self-healing， hemostatic， and myogenic abilities. The structure， biosynthetic principles， and preparation methods of bacterial cellulose were summarized in this paper. A comparative analysis was conducted on the functionalization modification technologies and principles of bacterial cellulose， including chemical， physical， and biological modifications. The application of functionalized bacterial cellulose was dissected in wound dressings， and the development of its application in wound dressing was also prospected.